新皇冠体育

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Cell:重磅!首次构建出人头颈癌的完整细胞图谱

作者:
来源:
发布时间:
2018/04/17
【摘要】:
头颈部肿瘤在美国和全世界范围内都是较为常见的,是癌症相关疾病和死亡的第六大原因。虽然这种肿瘤经常在舌头、脸颊或喉咙中发现,这就使得可通过外科手术摘除它,但是它能够通过淋巴结进一步扩散

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新皇冠体育 GENJUYIXIANGXINDEYANJIU,HANYOUJINGLIBUFENFASHENGSHANGPI-JIANZHIZHUANHUA(epithelial-to-mesenchymal transition, EMT)DEXIBAODETOUJINGBUZHONGLIUGENGKENENGQINRUHEKUOSANDAOSHENTIDEQITABUWEI。LAIZIMEIGUOMASHENGZONGYIYUANHEBULUODEYANJIURENYUANDENGYANJIUJIGOUDEYANJIURENYUANZAIZHEIXIANGXINDEYANJIUZHONGGOUJIANCHUTOUJINGAIDESHOUGETUPU,JIESHICHUYUANFAXINGTOUJINGBUZHONGLIUHETAMENDEZHUANYILIUZHONGDEHENDUOZHONGBUTONGLEIXINGDEAIXIBAOHEFEIAIXIBAO。EMTHUIRANGZHEIXIEXIBAOYOUZHENGQIPAILIEDEKUAIZHUANGJIEGOUZHUANHUAWEIBUGUIZEDEYANSHENDAOZHOUWEIHUANJINGZHONGDEJIEGOU。ZHEIXIEFAXIANTIGONGLEGUANYUTOUJINGAIRUHEZHUANYIDEZHONGYAOXIANSUO,BINGQIEKENENGDUIQITADECHANGJIANAIZHENGCHANSHENGYINGXIANG。XIANGGUANYANJIUJIEGUOFABIAOZAI2017NIAN12YUE14RIDECellQIKANSHANG,LUNWENBIAOTIWEI“Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer”。

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新皇冠体育 LUNWENGONGTONGTONGXINZUOZHE、MASHENGZONGYIYUANAIZHENGZHONGXINDEBradley E. BernsteinBOSHISHUO,“ZHEISHIRENZHONGLIUZHONGFASHENGDEZHEIZHONGJIEGOUZHUANBIANDEZUIWEIQINGXIDETUPU。DUONIANLAI,RENMENYIZHIDAOXIBAONENGGOUSHIQUTAMENYUZHOUWEIZUZHIZHIJIANDELIANJIE,BIANDEGENGJUQIANYIXING,DANSHIZHEIYIDIANZAIRENAIZHENGZHONGHESHI、RUHEHENALIFASHENGYIZHICUNZAIZHEZHENGLUN。”

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新皇冠体育 LUNWENDIYIZUOZHE、HAFOYIXUEYUANDESidharth V. PuramBOSHISHUO,“JINGUANWOMENJIDONGRENXINDIDUITOUJINGBUZHONGLIUZHONGDEMEIZHONGXIBAOLEIXINGTIGONGLEJIFENGFUERYOUXIANGXIDEMIAOSHU,DANSHIWOMENHENKUAIYISHIDAODUTEDEAIXIBAOCUNZAIYUYIXIEHUANZHEZHONG,DANBUCUNZAIQITADEHUANZHEZHONG。WOMENXIANGYAOZHIDAOZHEIXIEAIXIBAOSHIFOUNENGGOUJIESHIWEIHEYIXIEZHONGLIUKUOSANDAOBOZIHEBOZIYIXIADEBUWEI,ERQITADEZHONGLIUZEBUHUIKUOSA。”

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LUNWENGONGTONGTONGXINZUOZHE、HAFOYIXUEYUANDEDerrick T. LinBOSHISHUO,“WOMENKENENGNENGGOUBIWOMENDANGQIANDEZHONGLIUFENQIXITONGGENGJIAZHUNQUEDIYUCENAXIEHUANZHEJIANGHUICUNZAIZHEGENGCHADEYUHOU。YUCENAXIEHUANZHEJIANGHUIFASHENGLINBAJIEZHUANYINENGGOUGENGHAODIYOUHUAWOMENDEZHILIAOCELVE。ZHEIZHONGJIANJIEYEKENENGDAOZHIRENMENKAIFACHUBAXIANGZHEIGEGUOCHENGHEZUZHICONGYUANFABUWEIJINXINGZHUANYIDEXINLIAOFA,JIANYUZHONGLIUZHUANYISHIZUINANZHILIAODEWENTIZHIYI,YESHIAIZHENGHUANZHEWUFACUNHUODEZUIDAYUANYINZHIYI,ZHEIXIEFAXIANKAIPILEYIGEQUANXINDEYANJIULINGYU。”

CANKAOZILIAO:

Sidharth V. Puram, Itay Tirosh, Anuraag S. Parikh et al. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell, 14 December 2017, 171(7), 1611–1624, doi:10.1016/j.cell.2017.10.044